Memory B Cell Function in HIV-Infected Children—Decreased Memory B Cells Despite ART
نویسندگان
چکیده
منابع مشابه
Characterising B cell numbers and memory B cells in HIV infected and uninfected Malawian adults
BACKGROUND Untreated human immunodeficiency virus (HIV) disease disrupts B cell populations causing reduced memory and reduced naïve resting B cells leading to increases in specific co-infections and impaired responses to vaccines. To what extent antiretroviral treatment reverses these changes in an African population is uncertain. METHODS A cross-sectional study was performed. We recruited H...
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Human immunodeficiency virus (HIV) disease leads to impaired B cell and antibody responses through mechanisms that remain poorly defined. A unique memory B cell subpopulation (CD20(hi)/CD27(lo)/CD21(lo)) in human tonsillar tissues was recently defined by the expression of the inhibitory receptor Fc-receptor-like-4 (FCRL4). In this study, we describe a similar B cell subpopulation in the blood o...
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Background and purpose: Deficits of retrospective memory (RetM) and prospective memory (ProM), which are two primary components of episodic memory, have been reported in prior studies in HIV-infected individuals. The present study aimed to further elucidate the characteristics of prospective and retrospective memory complaints in HIV-infected individuals. Materials and Methods: We recruited 50...
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Memory B cells are generated in germinal centers (GC) and contribute to serological immunity by rapidly differentiating into plasma cells. Human memory B cells can be identified by the expression of CD27. These cells exhibit more rapid responses than naive (CD27-) B cells following stimulation in vitro, consistent with the heightened kinetics of secondary responses in vivo. CD27+ B cells expres...
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Protective antibodies in Plasmodium falciparum malaria are only acquired after years of repeated infections. Chronic malaria exposure is associated with a large increase in atypical memory B cells (MBCs) that resemble B cells expanded in a variety of persistent viral infections. Understanding the function of atypical MBCs and their relationship to classical MBCs will be critical to developing e...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2009
ISSN: 0031-3998,1530-0447
DOI: 10.1203/pdr.0b013e3181aa057d